ECT2-DGKG Fusion FISH Probe
The ECT2-DGKG Fusion FISH Probe is used to confirm a fusion of the ECT2 and DGKG genes. The fusion of the ECT2 and DGKG genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ECT2-DGKG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-RERE | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-REOR | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-REGO | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-REGR | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-REAQ | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-ORRE | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-OROR | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-ORGO | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-ORAQ | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-GORE | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-GOOR | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-GOGO | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-GOGR | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-GOAQ | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-GRRE | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-GROR | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-GRGO | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-GRGR | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-GRAQ | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-AQRE | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-AQOR | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-AQGO | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-AQGR | 20 (40 μL) | 200 μL |
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| ECT2-DGKG-20-AQAQ | 20 (40 μL) | 200 μL |
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DGKG Gene Summary
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Diacylglycerol Kinase Gamma
Chromosome: CHR3: 185864989 -186080023
Locus: 3q27.2-q27.3
ECT2 Gene Summary
The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
Gene Name: Epithelial Cell Transforming 2
Chromosome: CHR3: 172472297 -172539263
Locus: 3q26.31
Gene Diseases
The ECT2 DGKG Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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