ECE1-PLA2G5 Fusion FISH Probe
The ECE1-PLA2G5 Fusion FISH Probe is used to confirm a fusion of the ECE1 and PLA2G5 genes. The fusion of the ECE1 and PLA2G5 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ECE1-PLA2G5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-RERE | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-REOR | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-REGO | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-REGR | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-REAQ | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-ORRE | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-OROR | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-ORGO | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-ORAQ | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-GORE | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-GOOR | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-GOGO | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-GOGR | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-GOAQ | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-GRRE | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-GROR | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-GRGO | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-GRGR | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-GRAQ | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-AQRE | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-AQOR | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-AQGO | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-AQGR | 20 (40 μL) | 200 μL |
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| ECE1-PLA2G5-20-AQAQ | 20 (40 μL) | 200 μL |
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ECE1 Gene Summary
The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]
Gene Name: Endothelin Converting Enzyme 1
Chromosome: CHR1: 21543739 -21672034
Locus: 1p36.12
PLA2G5 Gene Summary
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Phospholipase A2 Group V
Chromosome: CHR1: 20396700 -20418394
Locus: 1p36.13
Gene Diseases
The ECE1 PLA2G5 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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