EBNA1BP2-FMO3 Fusion FISH Probe
The EBNA1BP2-FMO3 Fusion FISH Probe is used to confirm a fusion of the EBNA1BP2 and FMO3 genes. The fusion of the EBNA1BP2 and FMO3 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EBNA1BP2-FMO3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-RERE | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-REOR | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-REGO | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-REGR | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-REAQ | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-ORRE | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-OROR | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-ORGO | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-ORAQ | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-GORE | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-GOOR | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-GOGO | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-GOGR | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-GOAQ | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-GRRE | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-GROR | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-GRGO | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-GRGR | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-GRAQ | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-AQRE | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-AQOR | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-AQGO | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-AQGR | 20 (40 μL) | 200 μL |
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| EBNA1BP2-FMO3-20-AQAQ | 20 (40 μL) | 200 μL |
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FMO3 Gene Summary
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]
Gene Name: Flavin Containing Monooxygenase 3
Chromosome: CHR1: 171060017 -171086959
Locus: 1q24.3
EBNA1BP2 Gene Summary
The EBNA1 Binding Protein 2 (EBNA1BP2) gene is located on chr1 :43629844-43638241 at 1p34.2.
Gene Name: EBNA1 Binding Protein 2
Chromosome: CHR1: 43629844 -43638241
Locus: 1p34.2
Gene Diseases
The EBNA1BP2 FMO3 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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