DYRK1A-RUNX1 Fusion FISH Probe
The DYRK1A-RUNX1 Fusion FISH Probe is used to confirm a fusion of the DYRK1A and RUNX1 genes. The fusion of the DYRK1A and RUNX1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DYRK1A-RUNX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-RERE | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-REOR | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-REGO | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-REGR | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-REAQ | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-ORRE | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-OROR | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-ORGO | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-GORE | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-GOOR | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-GOGO | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-GOGR | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-GRRE | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-GROR | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-GRGO | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-GRGR | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-AQRE | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-AQOR | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-AQGO | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-AQGR | 20 (40 μL) | 200 μL |
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| DYRK1A-RUNX1-20-AQAQ | 20 (40 μL) | 200 μL |
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RUNX1 Gene Summary
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Runt Related Transcription Factor 1
Chromosome: CHR21: 36160097 -36421595
Locus: 21q22.12
DYRK1A Gene Summary
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A
Chromosome: CHR21: 38739858 -38887679
Locus: 21q22.13
Gene Diseases
The DYRK1A RUNX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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