DYNC2LI1-KCNN3 Fusion FISH Probe
The DYNC2LI1-KCNN3 Fusion FISH Probe is used to confirm a fusion of the DYNC2LI1 and KCNN3 genes. The fusion of the DYNC2LI1 and KCNN3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DYNC2LI1-KCNN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-RERE | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-REOR | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-REGO | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-REGR | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-REAQ | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-ORRE | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-OROR | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-ORGO | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-GORE | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-GOOR | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-GOGO | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-GOGR | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-GRRE | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-GROR | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-GRGO | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-GRGR | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-AQRE | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-AQOR | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-AQGO | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-AQGR | 20 (40 μL) | 200 μL |
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| DYNC2LI1-KCNN3-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNN3 Gene Summary
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Name: Potassium Calcium-activated Channel Subfamily N Member 3
Chromosome: CHR1: 154669941 -154842754
Locus: 1q21.3
DYNC2LI1 Gene Summary
This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
Gene Name: Dynein Cytoplasmic 2 Light Intermediate Chain 1
Chromosome: CHR2: 44001177 -44037149
Locus: 2p21
Gene Diseases
The DYNC2LI1 KCNN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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