DYNC1LI1-MRPS11 Fusion FISH Probe
The DYNC1LI1-MRPS11 Fusion FISH Probe is used to confirm a fusion of the DYNC1LI1 and MRPS11 genes. The fusion of the DYNC1LI1 and MRPS11 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DYNC1LI1-MRPS11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-RERE | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-REOR | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-REGO | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-REGR | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-REAQ | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-ORRE | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-OROR | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-ORGO | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-ORAQ | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-GORE | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-GOOR | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-GOGO | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-GOGR | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-GOAQ | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-GRRE | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-GROR | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-GRGO | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-GRGR | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-GRAQ | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-AQRE | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-AQOR | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-AQGO | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-AQGR | 20 (40 μL) | 200 μL |
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| DYNC1LI1-MRPS11-20-AQAQ | 20 (40 μL) | 200 μL |
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DYNC1LI1 Gene Summary
The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]
Gene Name: Dynein Cytoplasmic 1 Light Intermediate Chain 1
Chromosome: CHR3: 32567462 -32612366
Locus: 3p22.3
MRPS11 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Gene Name: Mitochondrial Ribosomal Protein S11
Chromosome: CHR15: 89010683 -89021861
Locus: 15q25.3
Gene Diseases
The DYNC1LI1 MRPS11 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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