DYNC1H1-PPP2R5C Fusion FISH Probe
The DYNC1H1-PPP2R5C Fusion FISH Probe is used to confirm a fusion of the DYNC1H1 and PPP2R5C genes. The fusion of the DYNC1H1 and PPP2R5C genes has been associated with Breast Invasive Carcinoma, and Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DYNC1H1-PPP2R5C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-RERE | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-REOR | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-REGO | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-REGR | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-REAQ | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-ORRE | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-OROR | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-ORGO | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-ORAQ | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-GORE | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-GOOR | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-GOGO | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-GOGR | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-GOAQ | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-GRRE | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-GROR | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-GRGO | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-GRGR | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-GRAQ | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-AQRE | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-AQOR | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-AQGO | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-AQGR | 20 (40 μL) | 200 μL |
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| DYNC1H1-PPP2R5C-20-AQAQ | 20 (40 μL) | 200 μL |
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DYNC1H1 Gene Summary
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
Gene Name: Dynein Cytoplasmic 1 Heavy Chain 1
Chromosome: CHR14: 102430864 -102517135
Locus: 14q32.31
PPP2R5C Gene Summary
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 2 Regulatory Subunit B'gamma
Chromosome: CHR14: 102228134 -102394328
Locus: 14q32.31
Gene Diseases
The DYNC1H1 PPP2R5C Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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