DYNC1H1-EIF5 Fusion FISH Probe
The DYNC1H1-EIF5 Fusion FISH Probe is used to confirm a fusion of the DYNC1H1 and EIF5 genes. The fusion of the DYNC1H1 and EIF5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DYNC1H1-EIF5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-RERE | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-REOR | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-REGO | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-REGR | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-REAQ | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-ORRE | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-OROR | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-ORGO | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-ORAQ | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-GORE | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-GOOR | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-GOGO | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-GOGR | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-GOAQ | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-GRRE | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-GROR | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-GRGO | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-GRGR | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-GRAQ | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-AQRE | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-AQOR | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-AQGO | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-AQGR | 20 (40 μL) | 200 μL |
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| DYNC1H1-EIF5-20-AQAQ | 20 (40 μL) | 200 μL |
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DYNC1H1 Gene Summary
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
Gene Name: Dynein Cytoplasmic 1 Heavy Chain 1
Chromosome: CHR14: 102430864 -102517135
Locus: 14q32.31
EIF5 Gene Summary
Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]
Gene Name: Eukaryotic Translation Initiation Factor 5
Chromosome: CHR14: 103800492 -103811361
Locus: 14q32.32
Gene Diseases
The DYNC1H1 EIF5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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