DUSP14-ATP6V0A1 Fusion FISH Probe
The DUSP14-ATP6V0A1 Fusion FISH Probe is used to confirm a fusion of the DUSP14 and ATP6V0A1 genes. The fusion of the DUSP14 and ATP6V0A1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DUSP14-ATP6V0A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-RERE | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-REOR | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-REGO | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-REGR | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-REAQ | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-ORRE | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-OROR | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-ORGO | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-GORE | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-GOOR | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-GOGO | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-GOGR | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-GRRE | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-GROR | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-GRGO | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-GRGR | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-AQRE | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-AQOR | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-AQGO | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-AQGR | 20 (40 μL) | 200 μL |
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| DUSP14-ATP6V0A1-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP6V0A1 Gene Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: ATPase H+ Transporting V0 Subunit A1
Chromosome: CHR17: 40610861 -40674597
Locus: 17q21.2
DUSP14 Gene Summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Gene Name: Dual Specificity Phosphatase 14
Chromosome: CHR17: 35849950 -35873588
Locus: 17q12
Gene Diseases
The DUSP14 ATP6V0A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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