DSE-GRIN2A Fusion FISH Probe
The DSE-GRIN2A Fusion FISH Probe is used to confirm a fusion of the DSE and GRIN2A genes. The fusion of the DSE and GRIN2A genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DSE-GRIN2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-RERE | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-REOR | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-REGO | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-REGR | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-REAQ | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-ORRE | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-OROR | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-ORGO | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-GORE | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-GOOR | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-GOGO | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-GOGR | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-GRRE | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-GROR | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-GRGO | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-GRGR | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-AQRE | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-AQOR | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-AQGO | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-AQGR | 20 (40 μL) | 200 μL |
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| DSE-GRIN2A-20-AQAQ | 20 (40 μL) | 200 μL |
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GRIN2A Gene Summary
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Glutamate Ionotropic Receptor NMDA Type Subunit 2A
Chromosome: CHR16: 9847264 -10276611
Locus: 16p13.2
DSE Gene Summary
The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016]
Gene Name: Dermatan Sulfate Epimerase
Chromosome: CHR6: 116601282 -116759442
Locus: 6q22.1
Gene Diseases
The DSE GRIN2A Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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