DSCR3-NIPBL Fusion FISH Probe
The DSCR3-NIPBL Fusion FISH Probe is used to confirm a fusion of the DSCR3 and NIPBL genes. The fusion of the DSCR3 and NIPBL genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DSCR3-NIPBL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-RERE | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-REOR | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-REGO | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-REGR | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-OROR | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-GORE | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-GROR | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| DSCR3-NIPBL-20-AQAQ | 20 (40 μL) | 200 μL |
|
DSCR3 Gene Summary
The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and cognitive disability. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region and is predictated to contain eight exons. DSCR3 is expressed in most tissues examined. [provided by RefSeq, Jul 2008]
Gene Name: DSCR3 Arrestin Fold Containing
Chromosome: CHR21: 38595725 -38639833
Locus: 21q22.13
NIPBL Gene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: NIPBL, Cohesin Loading Factor
Chromosome: CHR5: 36876860 -37065921
Locus: 5p13.2
Gene Diseases
The DSCR3 NIPBL Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|