DSCAML1-MPZL2 Fusion FISH Probe
The DSCAML1-MPZL2 Fusion FISH Probe is used to confirm a fusion of the DSCAML1 and MPZL2 genes. The fusion of the DSCAML1 and MPZL2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DSCAML1-MPZL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-RERE | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-REOR | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-REGO | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-REGR | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-REAQ | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-ORRE | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-OROR | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-ORGO | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-GORE | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-GOOR | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-GOGO | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-GOGR | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-GRRE | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-GROR | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-GRGO | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-GRGR | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-AQRE | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-AQOR | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-AQGO | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-AQGR | 20 (40 μL) | 200 μL |
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| DSCAML1-MPZL2-20-AQAQ | 20 (40 μL) | 200 μL |
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MPZL2 Gene Summary
Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Myelin Protein Zero Like 2
Chromosome: CHR11: 118124130 -118135251
Locus: 11q23.3
DSCAML1 Gene Summary
The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type. [provided by RefSeq, Sep 2016]
Gene Name: DS Cell Adhesion Molecule Like 1
Chromosome: CHR11: 117298488 -117667976
Locus: 11q23.3
Gene Diseases
The DSCAML1 MPZL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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