DPYD-RGS5 Fusion FISH Probe
The DPYD-RGS5 Fusion FISH Probe is used to confirm a fusion of the DPYD and RGS5 genes. The fusion of the DPYD and RGS5 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DPYD-RGS5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-RERE | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-REOR | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-REGO | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-REGR | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-REAQ | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-ORRE | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-OROR | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-ORGO | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-ORAQ | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-GORE | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-GOOR | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-GOGO | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-GOGR | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-GOAQ | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-GRRE | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-GROR | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-GRGO | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-GRGR | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-GRAQ | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-AQRE | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-AQOR | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-AQGO | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-AQGR | 20 (40 μL) | 200 μL |
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| DPYD-RGS5-20-AQAQ | 20 (40 μL) | 200 μL |
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DPYD Gene Summary
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Name: Dihydropyrimidine Dehydrogenase
Chromosome: CHR1: 97543299 -98386615
Locus: 1p21.3
RGS5 Gene Summary
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]
Gene Name: Regulator Of G Protein Signaling 5
Chromosome: CHR1: 163112088 -163172963
Locus: 1q23.3
Gene Diseases
The DPYD RGS5 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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