DPP3-PACS1 Fusion FISH Probe
The DPP3-PACS1 Fusion FISH Probe is used to confirm a fusion of the DPP3 and PACS1 genes. The fusion of the DPP3 and PACS1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DPP3-PACS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-RERE | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-REOR | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-REGO | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-REGR | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-REAQ | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-ORRE | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-OROR | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-ORGO | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-GORE | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-GOOR | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-GOGO | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-GOGR | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-GRRE | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-GROR | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-GRGO | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-GRGR | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-AQRE | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-AQOR | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-AQGO | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-AQGR | 20 (40 μL) | 200 μL |
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| DPP3-PACS1-20-AQAQ | 20 (40 μL) | 200 μL |
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DPP3 Gene Summary
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Dipeptidyl Peptidase 3
Chromosome: CHR11: 66247879 -66277130
Locus: 11q13.2
PACS1 Gene Summary
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]
Gene Name: Phosphofurin Acidic Cluster Sorting Protein 1
Chromosome: CHR11: 65837823 -66012213
Locus: 11q13.1-q13.2
Gene Diseases
The DPP3 PACS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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