DPM1-EZR Fusion FISH Probe
The DPM1-EZR Fusion FISH Probe is used to confirm a fusion of the DPM1 and EZR genes. The fusion of the DPM1 and EZR genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DPM1-EZR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-RERE | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-REOR | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-REGO | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-REGR | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-REAQ | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-ORRE | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-OROR | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-ORGO | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-ORAQ | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-GORE | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-GOOR | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-GOGO | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-GOGR | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-GOAQ | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-GRRE | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-GROR | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-GRGO | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-GRGR | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-GRAQ | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-AQRE | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-AQOR | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-AQGO | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-AQGR | 20 (40 μL) | 200 μL |
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| DPM1-EZR-20-AQAQ | 20 (40 μL) | 200 μL |
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EZR Gene Summary
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ezrin
Chromosome: CHR6: 159186772 -159240456
Locus: 6q25.3
DPM1 Gene Summary
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Gene Name: Dolichyl-phosphate Mannosyltransferase Subunit 1, Catalytic
Chromosome: CHR20: 49551404 -49575060
Locus: 20q13.13
Gene Diseases
The DPM1 EZR Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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