DPM1-CYP4F12 Fusion FISH Probe
The DPM1-CYP4F12 Fusion FISH Probe is used to confirm a fusion of the DPM1 and CYP4F12 genes. The fusion of the DPM1 and CYP4F12 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DPM1-CYP4F12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-RERE | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-REOR | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-REGO | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-REGR | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-OROR | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-GORE | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-GROR | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| DPM1-CYP4F12-20-AQAQ | 20 (40 μL) | 200 μL |
|
DPM1 Gene Summary
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Gene Name: Dolichyl-phosphate Mannosyltransferase Subunit 1, Catalytic
Chromosome: CHR20: 49551404 -49575060
Locus: 20q13.13
CYP4F12 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Name: Cytochrome P450 Family 4 Subfamily F Member 12
Chromosome: CHR19: 15783827 -15807984
Locus: 19p13.12
Gene Diseases
The DPM1 CYP4F12 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|