DPH1-RPA1 Fusion FISH Probe
The DPH1-RPA1 Fusion FISH Probe is used to confirm a fusion of the DPH1 and RPA1 genes. The fusion of the DPH1 and RPA1 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DPH1-RPA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-RERE | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-REOR | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-REGO | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-REGR | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-REAQ | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-ORRE | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-OROR | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-ORGO | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-GORE | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-GOOR | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-GOGO | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-GOGR | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-GRRE | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-GROR | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-GRGO | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-GRGR | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-AQRE | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-AQOR | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-AQGO | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-AQGR | 20 (40 μL) | 200 μL |
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| DPH1-RPA1-20-AQAQ | 20 (40 μL) | 200 μL |
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DPH1 Gene Summary
The protein encoded by this gene is an enzyme involved in the biosynthesis of diphthamide, a modified histidine found only in elongation factor-2 (EEF2). Diphthamide residues in EEF2 are targeted for ADP-ribosylation by diphtheria toxin and Pseudomonas exotoxin A. Defects in this gene have been associated with both ovarian cancer and autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies. [provided by RefSeq, Oct 2016]
Gene Name: Diphthamide Biosynthesis 1
Chromosome: CHR17: 1933430 -1946725
Locus: 17p13.3
RPA1 Gene Summary
This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017]
Gene Name: Replication Protein A1
Chromosome: CHR17: 1733272 -1802848
Locus: 17p13.3
Gene Diseases
The DPH1 RPA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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