DOT1L-LSM7 Fusion FISH Probe
The DOT1L-LSM7 Fusion FISH Probe is used to confirm a fusion of the DOT1L and LSM7 genes. The fusion of the DOT1L and LSM7 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DOT1L-LSM7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-RERE | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-REOR | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-REGO | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-REGR | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-REAQ | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-ORRE | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-OROR | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-ORGO | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-ORAQ | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-GORE | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-GOOR | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-GOGO | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-GOGR | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-GOAQ | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-GRRE | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-GROR | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-GRGO | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-GRGR | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-GRAQ | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-AQRE | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-AQOR | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-AQGO | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-AQGR | 20 (40 μL) | 200 μL |
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| DOT1L-LSM7-20-AQAQ | 20 (40 μL) | 200 μL |
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LSM7 Gene Summary
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Gene Name: LSM7 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated
Chromosome: CHR19: 2321519 -2328614
Locus: 19p13.3
DOT1L Gene Summary
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Gene Name: DOT1 Like Histone Lysine Methyltransferase
Chromosome: CHR19: 2164147 -2232577
Locus: 19p13.3
Gene Diseases
The DOT1L LSM7 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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