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DOT1L-BTBD2 Fusion FISH Probe

The DOT1L-BTBD2 Fusion FISH Probe is used to confirm a fusion of the DOT1L and BTBD2 genes. The fusion of the DOT1L and BTBD2 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
DOT1L-BTBD2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
DOT1L-BTBD2-20-RERE 20 (40 μL) 200 μL
DOT1L-BTBD2-20-REOR 20 (40 μL) 200 μL
DOT1L-BTBD2-20-REGO 20 (40 μL) 200 μL
DOT1L-BTBD2-20-REGR 20 (40 μL) 200 μL
DOT1L-BTBD2-20-REAQ 20 (40 μL) 200 μL
DOT1L-BTBD2-20-ORRE 20 (40 μL) 200 μL
DOT1L-BTBD2-20-OROR 20 (40 μL) 200 μL
DOT1L-BTBD2-20-ORGO 20 (40 μL) 200 μL
DOT1L-BTBD2-20-ORAQ 20 (40 μL) 200 μL
DOT1L-BTBD2-20-GORE 20 (40 μL) 200 μL
DOT1L-BTBD2-20-GOOR 20 (40 μL) 200 μL
DOT1L-BTBD2-20-GOGO 20 (40 μL) 200 μL
DOT1L-BTBD2-20-GOGR 20 (40 μL) 200 μL
DOT1L-BTBD2-20-GOAQ 20 (40 μL) 200 μL
DOT1L-BTBD2-20-GRRE 20 (40 μL) 200 μL
DOT1L-BTBD2-20-GROR 20 (40 μL) 200 μL
DOT1L-BTBD2-20-GRGO 20 (40 μL) 200 μL
DOT1L-BTBD2-20-GRGR 20 (40 μL) 200 μL
DOT1L-BTBD2-20-GRAQ 20 (40 μL) 200 μL
DOT1L-BTBD2-20-AQRE 20 (40 μL) 200 μL
DOT1L-BTBD2-20-AQOR 20 (40 μL) 200 μL
DOT1L-BTBD2-20-AQGO 20 (40 μL) 200 μL
DOT1L-BTBD2-20-AQGR 20 (40 μL) 200 μL
DOT1L-BTBD2-20-AQAQ 20 (40 μL) 200 μL

BTBD2 Gene Summary

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008]

Gene Name: BTB Domain Containing 2

Chromosome: CHR19: 1985446 -2015702

Locus: 19p13.3

DOT1L Gene Summary

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]

Gene Name: DOT1 Like Histone Lysine Methyltransferase

Chromosome: CHR19: 2164147 -2232577

Locus: 19p13.3

Gene Diseases

The DOT1L BTBD2 Fusion has been associated with the following diseases:

Disease Name
Colon Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.