DOT1L-BTBD2 Fusion FISH Probe
The DOT1L-BTBD2 Fusion FISH Probe is used to confirm a fusion of the DOT1L and BTBD2 genes. The fusion of the DOT1L and BTBD2 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DOT1L-BTBD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-RERE | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-REOR | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-REGO | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-REGR | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-REAQ | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-ORRE | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-OROR | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-ORGO | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-GORE | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-GOOR | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-GOGO | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-GOGR | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-GRRE | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-GROR | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-GRGO | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-GRGR | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-AQRE | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-AQOR | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-AQGO | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-AQGR | 20 (40 μL) | 200 μL |
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| DOT1L-BTBD2-20-AQAQ | 20 (40 μL) | 200 μL |
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BTBD2 Gene Summary
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008]
Gene Name: BTB Domain Containing 2
Chromosome: CHR19: 1985446 -2015702
Locus: 19p13.3
DOT1L Gene Summary
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Gene Name: DOT1 Like Histone Lysine Methyltransferase
Chromosome: CHR19: 2164147 -2232577
Locus: 19p13.3
Gene Diseases
The DOT1L BTBD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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