DOCK4-NRCAM Fusion FISH Probe
The DOCK4-NRCAM Fusion FISH Probe is used to confirm a fusion of the DOCK4 and NRCAM genes. The fusion of the DOCK4 and NRCAM genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DOCK4-NRCAM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-RERE | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-REOR | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-REGO | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-REGR | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-REAQ | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-ORRE | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-OROR | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-ORGO | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-ORAQ | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-GORE | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-GOOR | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-GOGO | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-GOGR | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-GOAQ | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-GRRE | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-GROR | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-GRGO | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-GRGR | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-GRAQ | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-AQRE | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-AQOR | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-AQGO | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-AQGR | 20 (40 μL) | 200 μL |
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| DOCK4-NRCAM-20-AQAQ | 20 (40 μL) | 200 μL |
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NRCAM Gene Summary
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Neuronal Cell Adhesion Molecule
Chromosome: CHR7: 107788070 -108096841
Locus: 7q31.1
DOCK4 Gene Summary
This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Dedicator Of Cytokinesis 4
Chromosome: CHR7: 111366163 -111846462
Locus: 7q31.1
Gene Diseases
The DOCK4 NRCAM Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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