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DOCK4-NRCAM Fusion FISH Probe

The DOCK4-NRCAM Fusion FISH Probe is used to confirm a fusion of the DOCK4 and NRCAM genes. The fusion of the DOCK4 and NRCAM genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
DOCK4-NRCAM-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
DOCK4-NRCAM-20-RERE 20 (40 μL) 200 μL
DOCK4-NRCAM-20-REOR 20 (40 μL) 200 μL
DOCK4-NRCAM-20-REGO 20 (40 μL) 200 μL
DOCK4-NRCAM-20-REGR 20 (40 μL) 200 μL
DOCK4-NRCAM-20-REAQ 20 (40 μL) 200 μL
DOCK4-NRCAM-20-ORRE 20 (40 μL) 200 μL
DOCK4-NRCAM-20-OROR 20 (40 μL) 200 μL
DOCK4-NRCAM-20-ORGO 20 (40 μL) 200 μL
DOCK4-NRCAM-20-ORAQ 20 (40 μL) 200 μL
DOCK4-NRCAM-20-GORE 20 (40 μL) 200 μL
DOCK4-NRCAM-20-GOOR 20 (40 μL) 200 μL
DOCK4-NRCAM-20-GOGO 20 (40 μL) 200 μL
DOCK4-NRCAM-20-GOGR 20 (40 μL) 200 μL
DOCK4-NRCAM-20-GOAQ 20 (40 μL) 200 μL
DOCK4-NRCAM-20-GRRE 20 (40 μL) 200 μL
DOCK4-NRCAM-20-GROR 20 (40 μL) 200 μL
DOCK4-NRCAM-20-GRGO 20 (40 μL) 200 μL
DOCK4-NRCAM-20-GRGR 20 (40 μL) 200 μL
DOCK4-NRCAM-20-GRAQ 20 (40 μL) 200 μL
DOCK4-NRCAM-20-AQRE 20 (40 μL) 200 μL
DOCK4-NRCAM-20-AQOR 20 (40 μL) 200 μL
DOCK4-NRCAM-20-AQGO 20 (40 μL) 200 μL
DOCK4-NRCAM-20-AQGR 20 (40 μL) 200 μL
DOCK4-NRCAM-20-AQAQ 20 (40 μL) 200 μL

NRCAM Gene Summary

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Name: Neuronal Cell Adhesion Molecule

Chromosome: CHR7: 107788070 -108096841

Locus: 7q31.1

DOCK4 Gene Summary

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]

Gene Name: Dedicator Of Cytokinesis 4

Chromosome: CHR7: 111366163 -111846462

Locus: 7q31.1

Gene Diseases

The DOCK4 NRCAM Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Papillary Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.