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DOCK3-TMIGD2 Fusion FISH Probe

The DOCK3-TMIGD2 Fusion FISH Probe is used to confirm a fusion of the DOCK3 and TMIGD2 genes. The fusion of the DOCK3 and TMIGD2 genes has been associated with Thymoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
DOCK3-TMIGD2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-RERE 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-REOR 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-REGO 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-REGR 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-REAQ 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-ORRE 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-OROR 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-ORGO 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-ORAQ 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-GORE 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-GOOR 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-GOGO 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-GOGR 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-GOAQ 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-GRRE 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-GROR 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-GRGO 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-GRGR 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-GRAQ 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-AQRE 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-AQOR 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-AQGO 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-AQGR 20 (40 μL) 200 μL
DOCK3-TMIGD2-20-AQAQ 20 (40 μL) 200 μL

DOCK3 Gene Summary

This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]

Gene Name: Dedicator Of Cytokinesis 3

Chromosome: CHR3: 50712671 -51421629

Locus: 3p21.2

TMIGD2 Gene Summary

The Transmembrane And Immunoglobulin Domain Containing 2 (TMIGD2) gene is located on chr19 :4292224-4302428 at 19p13.3.

Gene Name: Transmembrane And Immunoglobulin Domain Containing 2

Chromosome: CHR19: 4292224 -4302428

Locus: 19p13.3

Gene Diseases

The DOCK3 TMIGD2 Fusion has been associated with the following diseases:

Disease Name
Thymoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.