DOCK10-IL1RN Fusion FISH Probe
The DOCK10-IL1RN Fusion FISH Probe is used to confirm a fusion of the DOCK10 and IL1RN genes. The fusion of the DOCK10 and IL1RN genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DOCK10-IL1RN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-RERE | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-REOR | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-REGO | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-REGR | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-REAQ | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-ORRE | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-OROR | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-ORGO | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-ORAQ | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-GORE | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-GOOR | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-GOGO | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-GOGR | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-GOAQ | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-GRRE | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-GROR | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-GRGO | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-GRGR | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-GRAQ | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-AQRE | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-AQOR | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-AQGO | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-AQGR | 20 (40 μL) | 200 μL |
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| DOCK10-IL1RN-20-AQAQ | 20 (40 μL) | 200 μL |
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IL1RN Gene Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]
Gene Name: Interleukin 1 Receptor Antagonist
Chromosome: CHR2: 113875469 -113891593
Locus: 2q14.1
DOCK10 Gene Summary
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
Gene Name: Dedicator Of Cytokinesis 10
Chromosome: CHR2: 225629806 -225907330
Locus: 2q36.2
Gene Diseases
The DOCK10 IL1RN Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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