DNMT3B-MMP9 Fusion FISH Probe
The DNMT3B-MMP9 Fusion FISH Probe is used to confirm a fusion of the DNMT3B and MMP9 genes. The fusion of the DNMT3B and MMP9 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNMT3B-MMP9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-RERE | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-REOR | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-REGO | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-REGR | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-REAQ | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-ORRE | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-OROR | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-ORGO | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-GORE | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-GOOR | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-GOGO | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-GOGR | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-GRRE | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-GROR | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-GRGO | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-GRGR | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-AQRE | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-AQOR | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-AQGO | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-AQGR | 20 (40 μL) | 200 μL |
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| DNMT3B-MMP9-20-AQAQ | 20 (40 μL) | 200 μL |
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DNMT3B Gene Summary
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]
Gene Name: DNA Methyltransferase 3 Beta
Chromosome: CHR20: 31350190 -31397162
Locus: 20q11.21
MMP9 Gene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
Gene Name: Matrix Metallopeptidase 9
Chromosome: CHR20: 44637546 -44645200
Locus: 20q13.12
Gene Diseases
The DNMT3B MMP9 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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