DNMT3B-MDM4 Fusion FISH Probe
The DNMT3B-MDM4 Fusion FISH Probe is used to confirm a fusion of the DNMT3B and MDM4 genes. The fusion of the DNMT3B and MDM4 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNMT3B-MDM4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-RERE | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-REOR | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-REGO | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-REGR | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-REAQ | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-ORRE | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-OROR | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-ORGO | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-GORE | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-GOOR | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-GOGO | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-GOGR | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-GRRE | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-GROR | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-GRGO | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-GRGR | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-AQRE | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-AQOR | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-AQGO | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-AQGR | 20 (40 μL) | 200 μL |
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| DNMT3B-MDM4-20-AQAQ | 20 (40 μL) | 200 μL |
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DNMT3B Gene Summary
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]
Gene Name: DNA Methyltransferase 3 Beta
Chromosome: CHR20: 31350190 -31397162
Locus: 20q11.21
MDM4 Gene Summary
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Gene Name: MDM4, P53 Regulator
Chromosome: CHR1: 204485506 -204527248
Locus: 1q32.1
Gene Diseases
The DNMT3B MDM4 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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