DNMT3A-HADHA Fusion FISH Probe
The DNMT3A-HADHA Fusion FISH Probe is used to confirm a fusion of the DNMT3A and HADHA genes. The fusion of the DNMT3A and HADHA genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNMT3A-HADHA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-RERE | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-REOR | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-REGO | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-REGR | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-REAQ | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-ORRE | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-OROR | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-ORGO | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-GORE | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-GOOR | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-GOGO | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-GOGR | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-GRRE | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-GROR | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-GRGO | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-GRGR | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-AQRE | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-AQOR | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-AQGO | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-AQGR | 20 (40 μL) | 200 μL |
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| DNMT3A-HADHA-20-AQAQ | 20 (40 μL) | 200 μL |
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DNMT3A Gene Summary
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
Gene Name: DNA Methyltransferase 3 Alpha
Chromosome: CHR2: 25455844 -25565459
Locus: 2p23.3
HADHA Gene Summary
This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]
Gene Name: Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha
Chromosome: CHR2: 26413503 -26467594
Locus: 2p23.3
Gene Diseases
The DNMT3A HADHA Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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