DNMT3A-DTNB Fusion FISH Probe
The DNMT3A-DTNB Fusion FISH Probe is used to confirm a fusion of the DNMT3A and DTNB genes. The fusion of the DNMT3A and DTNB genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNMT3A-DTNB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-RERE | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-REOR | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-REGO | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-REGR | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-REAQ | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-ORRE | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-OROR | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-ORGO | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-GORE | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-GOOR | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-GOGO | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-GOGR | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-GRRE | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-GROR | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-GRGO | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-GRGR | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-AQRE | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-AQOR | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-AQGO | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-AQGR | 20 (40 μL) | 200 μL |
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| DNMT3A-DTNB-20-AQAQ | 20 (40 μL) | 200 μL |
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DNMT3A Gene Summary
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
Gene Name: DNA Methyltransferase 3 Alpha
Chromosome: CHR2: 25455844 -25565459
Locus: 2p23.3
DTNB Gene Summary
This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]
Gene Name: Dystrobrevin Beta
Chromosome: CHR2: 25600111 -25896503
Locus: 2p23.3
Gene Diseases
The DNMT3A DTNB Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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