DNMT1-ICAM3 Fusion FISH Probe
The DNMT1-ICAM3 Fusion FISH Probe is used to confirm a fusion of the DNMT1 and ICAM3 genes. The fusion of the DNMT1 and ICAM3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNMT1-ICAM3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-RERE | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-REOR | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-REGO | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-REGR | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-REAQ | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-ORRE | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-OROR | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-ORGO | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-GORE | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-GOOR | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-GOGO | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-GOGR | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-GRRE | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-GROR | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-GRGO | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-GRGR | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-AQRE | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-AQOR | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-AQGO | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-AQGR | 20 (40 μL) | 200 μL |
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| DNMT1-ICAM3-20-AQAQ | 20 (40 μL) | 200 μL |
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DNMT1 Gene Summary
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: DNA Methyltransferase 1
Chromosome: CHR19: 10244021 -10305755
Locus: 19p13.2
ICAM3 Gene Summary
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Gene Name: Intercellular Adhesion Molecule 3
Chromosome: CHR19: 10444451 -10450345
Locus: 19p13.2
Gene Diseases
The DNMT1 ICAM3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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