DNM2-TGIF1 Fusion FISH Probe
The DNM2-TGIF1 Fusion FISH Probe is used to confirm a fusion of the DNM2 and TGIF1 genes. The fusion of the DNM2 and TGIF1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNM2-TGIF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-RERE | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-REOR | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-REGO | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-REGR | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-REAQ | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-ORRE | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-OROR | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-ORGO | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-GORE | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-GOOR | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-GOGO | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-GOGR | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-GRRE | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-GROR | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-GRGO | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-GRGR | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-AQRE | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-AQOR | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-AQGO | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-AQGR | 20 (40 μL) | 200 μL |
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| DNM2-TGIF1-20-AQAQ | 20 (40 μL) | 200 μL |
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DNM2 Gene Summary
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Gene Name: Dynamin 2
Chromosome: CHR19: 10828728 -10942586
Locus: 19p13.2
TGIF1 Gene Summary
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Gene Name: TGFB Induced Factor Homeobox 1
Chromosome: CHR18: 3412071 -3458406
Locus: 18p11.31
Gene Diseases
The DNM2 TGIF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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