DNM2-RFX1 Fusion FISH Probe
The DNM2-RFX1 Fusion FISH Probe is used to confirm a fusion of the DNM2 and RFX1 genes. The fusion of the DNM2 and RFX1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNM2-RFX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-RERE | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-REOR | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-REGO | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-REGR | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-REAQ | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-ORRE | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-OROR | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-ORGO | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-GORE | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-GOOR | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-GOGO | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-GOGR | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-GRRE | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-GROR | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-GRGO | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-GRGR | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-AQRE | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-AQOR | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-AQGO | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-AQGR | 20 (40 μL) | 200 μL |
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| DNM2-RFX1-20-AQAQ | 20 (40 μL) | 200 μL |
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DNM2 Gene Summary
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Gene Name: Dynamin 2
Chromosome: CHR19: 10828728 -10942586
Locus: 19p13.2
RFX1 Gene Summary
This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016]
Gene Name: Regulatory Factor X1
Chromosome: CHR19: 14072341 -14117134
Locus: 19p13.12
Gene Diseases
The DNM2 RFX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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