DNM2-PDE4A Fusion FISH Probe
The DNM2-PDE4A Fusion FISH Probe is used to confirm a fusion of the DNM2 and PDE4A genes. The fusion of the DNM2 and PDE4A genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNM2-PDE4A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-RERE | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-REOR | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-REGO | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-REGR | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-REAQ | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-ORRE | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-OROR | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-ORGO | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-GORE | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-GOOR | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-GOGO | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-GOGR | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-GRRE | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-GROR | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-GRGO | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-GRGR | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-AQRE | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-AQOR | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-AQGO | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-AQGR | 20 (40 μL) | 200 μL |
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| DNM2-PDE4A-20-AQAQ | 20 (40 μL) | 200 μL |
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DNM2 Gene Summary
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Gene Name: Dynamin 2
Chromosome: CHR19: 10828728 -10942586
Locus: 19p13.2
PDE4A Gene Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Gene Name: Phosphodiesterase 4A
Chromosome: CHR19: 10527448 -10580307
Locus: 19p13.2
Gene Diseases
The DNM2 PDE4A Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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