DNM2-ILF3 Fusion FISH Probe
The DNM2-ILF3 Fusion FISH Probe is used to confirm a fusion of the DNM2 and ILF3 genes. The fusion of the DNM2 and ILF3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNM2-ILF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-RERE | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-REOR | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-REGO | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-REGR | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-REAQ | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-ORRE | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-OROR | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-ORGO | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-GORE | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-GOOR | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-GOGO | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-GOGR | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-GRRE | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-GROR | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-GRGO | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-GRGR | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-AQRE | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-AQOR | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-AQGO | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-AQGR | 20 (40 μL) | 200 μL |
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| DNM2-ILF3-20-AQAQ | 20 (40 μL) | 200 μL |
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DNM2 Gene Summary
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Gene Name: Dynamin 2
Chromosome: CHR19: 10828728 -10942586
Locus: 19p13.2
ILF3 Gene Summary
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
Gene Name: Interleukin Enhancer Binding Factor 3
Chromosome: CHR19: 10764936 -10803095
Locus: 19p13.2
Gene Diseases
The DNM2 ILF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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