DNM2-DAND5 Fusion FISH Probe
The DNM2-DAND5 Fusion FISH Probe is used to confirm a fusion of the DNM2 and DAND5 genes. The fusion of the DNM2 and DAND5 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNM2-DAND5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-RERE | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-REOR | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-REGO | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-REGR | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-REAQ | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-ORRE | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-OROR | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-ORGO | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-GORE | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-GOOR | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-GOGO | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-GOGR | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-GRRE | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-GROR | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-GRGO | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-GRGR | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-AQRE | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-AQOR | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-AQGO | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-AQGR | 20 (40 μL) | 200 μL |
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| DNM2-DAND5-20-AQAQ | 20 (40 μL) | 200 μL |
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DNM2 Gene Summary
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Gene Name: Dynamin 2
Chromosome: CHR19: 10828728 -10942586
Locus: 19p13.2
DAND5 Gene Summary
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]
Gene Name: DAN Domain BMP Antagonist Family Member 5
Chromosome: CHR19: 13080431 -13085567
Locus: 19p13.13
Gene Diseases
The DNM2 DAND5 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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