DNM2-ATG4D Fusion FISH Probe
The DNM2-ATG4D Fusion FISH Probe is used to confirm a fusion of the DNM2 and ATG4D genes. The fusion of the DNM2 and ATG4D genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNM2-ATG4D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-RERE | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-REOR | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-REGO | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-REGR | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-REAQ | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-ORRE | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-OROR | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-ORGO | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-GORE | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-GOOR | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-GOGO | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-GOGR | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-GRRE | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-GROR | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-GRGO | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-GRGR | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-AQRE | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-AQOR | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-AQGO | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-AQGR | 20 (40 μL) | 200 μL |
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| DNM2-ATG4D-20-AQAQ | 20 (40 μL) | 200 μL |
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DNM2 Gene Summary
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Gene Name: Dynamin 2
Chromosome: CHR19: 10828728 -10942586
Locus: 19p13.2
ATG4D Gene Summary
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Autophagy Related 4D Cysteine Peptidase
Chromosome: CHR19: 10654646 -10664094
Locus: 19p13.2
Gene Diseases
The DNM2 ATG4D Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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