DNM2-ANGPTL4 Fusion FISH Probe
The DNM2-ANGPTL4 Fusion FISH Probe is used to confirm a fusion of the DNM2 and ANGPTL4 genes. The fusion of the DNM2 and ANGPTL4 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNM2-ANGPTL4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-RERE | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-REOR | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-REGO | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-REGR | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-REAQ | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-ORRE | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-OROR | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-ORGO | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-GORE | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-GOOR | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-GOGO | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-GOGR | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-GRRE | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-GROR | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-GRGO | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-GRGR | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-AQRE | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-AQOR | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-AQGO | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-AQGR | 20 (40 μL) | 200 μL |
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| DNM2-ANGPTL4-20-AQAQ | 20 (40 μL) | 200 μL |
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DNM2 Gene Summary
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Gene Name: Dynamin 2
Chromosome: CHR19: 10828728 -10942586
Locus: 19p13.2
ANGPTL4 Gene Summary
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
Gene Name: Angiopoietin Like 4
Chromosome: CHR19: 8429010 -8439257
Locus: 19p13.2
Gene Diseases
The DNM2 ANGPTL4 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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