DNM1L-BICD1 Fusion FISH Probe
The DNM1L-BICD1 Fusion FISH Probe is used to confirm a fusion of the DNM1L and BICD1 genes. The fusion of the DNM1L and BICD1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNM1L-BICD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-RERE | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-REOR | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-REGO | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-REGR | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-REAQ | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-ORRE | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-OROR | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-ORGO | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-GORE | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-GOOR | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-GOGO | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-GOGR | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-GRRE | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-GROR | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-GRGO | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-GRGR | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-AQRE | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-AQOR | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-AQGO | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-AQGR | 20 (40 μL) | 200 μL |
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| DNM1L-BICD1-20-AQAQ | 20 (40 μL) | 200 μL |
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BICD1 Gene Summary
This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]
Gene Name: BICD Cargo Adaptor 1
Chromosome: CHR12: 32260184 -32531141
Locus: 12p11.21
DNM1L Gene Summary
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Gene Name: Dynamin 1 Like
Chromosome: CHR12: 32832136 -32898584
Locus: 12p11.21
Gene Diseases
The DNM1L BICD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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