DNM1-LCN2 Fusion FISH Probe
The DNM1-LCN2 Fusion FISH Probe is used to confirm a fusion of the DNM1 and LCN2 genes. The fusion of the DNM1 and LCN2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNM1-LCN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-RERE | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-REOR | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-REGO | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-REGR | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-REAQ | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-ORRE | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-OROR | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-ORGO | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-GORE | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-GOOR | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-GOGO | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-GOGR | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-GRRE | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-GROR | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-GRGO | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-GRGR | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-AQRE | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-AQOR | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-AQGO | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-AQGR | 20 (40 μL) | 200 μL |
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| DNM1-LCN2-20-AQAQ | 20 (40 μL) | 200 μL |
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DNM1 Gene Summary
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Dynamin 1
Chromosome: CHR9: 130965662 -131017527
Locus: 9q34.11
LCN2 Gene Summary
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]
Gene Name: Lipocalin 2
Chromosome: CHR9: 130911731 -130915734
Locus: 9q34.11
Gene Diseases
The DNM1 LCN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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