DNAJC2-SLC26A5 Fusion FISH Probe
The DNAJC2-SLC26A5 Fusion FISH Probe is used to confirm a fusion of the DNAJC2 and SLC26A5 genes. The fusion of the DNAJC2 and SLC26A5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNAJC2-SLC26A5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-RERE | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-REOR | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-REGO | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-REGR | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-REAQ | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-ORRE | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-OROR | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-ORGO | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-GORE | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-GOOR | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-GOGO | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-GOGR | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-GRRE | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-GROR | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-GRGO | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-GRGR | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-AQRE | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-AQOR | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-AQGO | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-AQGR | 20 (40 μL) | 200 μL |
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| DNAJC2-SLC26A5-20-AQAQ | 20 (40 μL) | 200 μL |
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DNAJC2 Gene Summary
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: DnaJ Heat Shock Protein Family (Hsp40) Member C2
Chromosome: CHR7: 102952920 -102985320
Locus: 7q22.1
SLC26A5 Gene Summary
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Gene Name: Solute Carrier Family 26 Member 5
Chromosome: CHR7: 102993176 -103086624
Locus: 7q22.1
Gene Diseases
The DNAJC2 SLC26A5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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