DNAJC2-PSMC2 Fusion FISH Probe
The DNAJC2-PSMC2 Fusion FISH Probe is used to confirm a fusion of the DNAJC2 and PSMC2 genes. The fusion of the DNAJC2 and PSMC2 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNAJC2-PSMC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-RERE | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-REOR | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-REGO | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-REGR | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-REAQ | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-ORRE | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-OROR | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-ORGO | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-GORE | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-GOOR | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-GOGO | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-GOGR | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-GRRE | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-GROR | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-GRGO | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-GRGR | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-AQRE | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-AQOR | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-AQGO | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-AQGR | 20 (40 μL) | 200 μL |
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| DNAJC2-PSMC2-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMC2 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]
Gene Name: Proteasome 26S Subunit, ATPase 2
Chromosome: CHR7: 102987970 -103009842
Locus: 7q22.1
DNAJC2 Gene Summary
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: DnaJ Heat Shock Protein Family (Hsp40) Member C2
Chromosome: CHR7: 102952920 -102985320
Locus: 7q22.1
Gene Diseases
The DNAJC2 PSMC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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