DNAH14-ARF1 Fusion FISH Probe
The DNAH14-ARF1 Fusion FISH Probe is used to confirm a fusion of the DNAH14 and ARF1 genes. The fusion of the DNAH14 and ARF1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DNAH14-ARF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-RERE | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-REOR | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-REGO | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-REGR | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-REAQ | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-ORRE | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-OROR | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-ORGO | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-GORE | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-GOOR | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-GOGO | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-GOGR | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-GRRE | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-GROR | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-GRGO | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-GRGR | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-AQRE | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-AQOR | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-AQGO | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-AQGR | 20 (40 μL) | 200 μL |
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| DNAH14-ARF1-20-AQAQ | 20 (40 μL) | 200 μL |
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ARF1 Gene Summary
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor 1
Chromosome: CHR1: 228270360 -228286913
Locus: 1q42.13
DNAH14 Gene Summary
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]
Gene Name: Dynein Axonemal Heavy Chain 14
Chromosome: CHR1: 225117355 -225586996
Locus: 1q42.12
Gene Diseases
The DNAH14 ARF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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