DMXL1-NANS Fusion FISH Probe
The DMXL1-NANS Fusion FISH Probe is used to confirm a fusion of the DMXL1 and NANS genes. The fusion of the DMXL1 and NANS genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DMXL1-NANS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-RERE | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-REOR | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-REGO | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-REGR | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-REAQ | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-ORRE | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-OROR | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-ORGO | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-ORAQ | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-GORE | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-GOOR | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-GOGO | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-GOGR | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-GOAQ | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-GRRE | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-GROR | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-GRGO | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-GRGR | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-GRAQ | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-AQRE | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-AQOR | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-AQGO | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-AQGR | 20 (40 μL) | 200 μL |
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| DMXL1-NANS-20-AQAQ | 20 (40 μL) | 200 μL |
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DMXL1 Gene Summary
The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Gene Name: Dmx Like 1
Chromosome: CHR5: 118407083 -118584822
Locus: 5q23.1
NANS Gene Summary
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]
Gene Name: N-acetylneuraminate Synthase
Chromosome: CHR9: 100818958 -100845365
Locus: 9q22.33
Gene Diseases
The DMXL1 NANS Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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