DMTF1-SEMA3D Fusion FISH Probe
The DMTF1-SEMA3D Fusion FISH Probe is used to confirm a fusion of the DMTF1 and SEMA3D genes. The fusion of the DMTF1 and SEMA3D genes has been associated with Brain Lower Grade Glioma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DMTF1-SEMA3D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-RERE | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-REOR | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-REGO | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-REGR | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-REAQ | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-ORRE | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-OROR | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-ORGO | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-ORAQ | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-GORE | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-GOOR | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-GOGO | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-GOGR | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-GOAQ | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-GRRE | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-GROR | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-GRGO | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-GRGR | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-GRAQ | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-AQRE | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-AQOR | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-AQGO | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-AQGR | 20 (40 μL) | 200 μL |
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| DMTF1-SEMA3D-20-AQAQ | 20 (40 μL) | 200 μL |
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DMTF1 Gene Summary
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Name: Cyclin D Binding Myb Like Transcription Factor 1
Chromosome: CHR7: 86781676 -86825648
Locus: 7q21.12
SEMA3D Gene Summary
This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin like domain and a C-terminal basic domain. The protein encoded by this gene binds neuropilin and plays an important role in cardiovascular development. [provided by RefSeq, Aug 2016]
Gene Name: Semaphorin 3D
Chromosome: CHR7: 84624871 -84751247
Locus: 7q21.11
Gene Diseases
The DMTF1 SEMA3D Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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