DMTF1-GRM3 Fusion FISH Probe
The DMTF1-GRM3 Fusion FISH Probe is used to confirm a fusion of the DMTF1 and GRM3 genes. The fusion of the DMTF1 and GRM3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DMTF1-GRM3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-RERE | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-REOR | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-REGO | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-REGR | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-REAQ | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-ORRE | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-OROR | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-ORGO | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-GORE | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-GOOR | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-GOGO | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-GOGR | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-GRRE | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-GROR | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-GRGO | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-GRGR | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-AQRE | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-AQOR | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-AQGO | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-AQGR | 20 (40 μL) | 200 μL |
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| DMTF1-GRM3-20-AQAQ | 20 (40 μL) | 200 μL |
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GRM3 Gene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
Gene Name: Glutamate Metabotropic Receptor 3
Chromosome: CHR7: 86273229 -86494192
Locus: 7q21.11-q21.12
DMTF1 Gene Summary
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Name: Cyclin D Binding Myb Like Transcription Factor 1
Chromosome: CHR7: 86781676 -86825648
Locus: 7q21.12
Gene Diseases
The DMTF1 GRM3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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