DMPK-RCN3 Fusion FISH Probe
The DMPK-RCN3 Fusion FISH Probe is used to confirm a fusion of the DMPK and RCN3 genes. The fusion of the DMPK and RCN3 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DMPK-RCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-RERE | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-REOR | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-REGO | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-REGR | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-OROR | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-GORE | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-GROR | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| DMPK-RCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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DMPK Gene Summary
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]
Gene Name: DM1 Protein Kinase
Chromosome: CHR19: 46272975 -46285815
Locus: 19q13.32
RCN3 Gene Summary
The Reticulocalbin 3 (RCN3) gene is located on chr19 :50030874-50046890 at 19q13.33.
Gene Name: Reticulocalbin 3
Chromosome: CHR19: 50030874 -50046890
Locus: 19q13.33
Gene Diseases
The DMPK RCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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