DMGDH-NMNAT2 Fusion FISH Probe
The DMGDH-NMNAT2 Fusion FISH Probe is used to confirm a fusion of the DMGDH and NMNAT2 genes. The fusion of the DMGDH and NMNAT2 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DMGDH-NMNAT2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-RERE | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-REOR | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-REGO | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-REGR | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-REAQ | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-ORRE | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-OROR | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-ORGO | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-GORE | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-GOOR | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-GOGO | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-GOGR | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-GRRE | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-GROR | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-GRGO | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-GRGR | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-AQRE | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-AQOR | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-AQGO | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-AQGR | 20 (40 μL) | 200 μL |
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| DMGDH-NMNAT2-20-AQAQ | 20 (40 μL) | 200 μL |
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NMNAT2 Gene Summary
This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nicotinamide Nucleotide Adenylyltransferase 2
Chromosome: CHR1: 183217371 -183387634
Locus: 1q25.3
DMGDH Gene Summary
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Dimethylglycine Dehydrogenase
Chromosome: CHR5: 78293428 -78365449
Locus: 5q14.1
Gene Diseases
The DMGDH NMNAT2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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