DMC1-DNAL4 Fusion FISH Probe
The DMC1-DNAL4 Fusion FISH Probe is used to confirm a fusion of the DMC1 and DNAL4 genes. The fusion of the DMC1 and DNAL4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DMC1-DNAL4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-RERE | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-REOR | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-REGO | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-REGR | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-REAQ | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-ORRE | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-OROR | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-ORGO | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-ORAQ | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-GORE | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-GOOR | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-GOGO | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-GOGR | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-GOAQ | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-GRRE | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-GROR | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-GRGO | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-GRGR | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-GRAQ | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-AQRE | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-AQOR | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-AQGO | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-AQGR | 20 (40 μL) | 200 μL |
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| DMC1-DNAL4-20-AQAQ | 20 (40 μL) | 200 μL |
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DNAL4 Gene Summary
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]
Gene Name: Dynein Axonemal Light Chain 4
Chromosome: CHR22: 39174512 -39190161
Locus: 22q13.1
DMC1 Gene Summary
This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: DNA Meiotic Recombinase 1
Chromosome: CHR22: 38914953 -38966189
Locus: 22q13.1
Gene Diseases
The DMC1 DNAL4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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