DLK1-STAT6 Fusion FISH Probe
The DLK1-STAT6 Fusion FISH Probe is used to confirm a fusion of the DLK1 and STAT6 genes. The fusion of the DLK1 and STAT6 genes has been associated with Adrenocortical Carcinoma, and Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DLK1-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| DLK1-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
DLK1 Gene Summary
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]
Gene Name: Delta Like Non-canonical Notch Ligand 1
Chromosome: CHR14: 101193201 -101201467
Locus: 14q32.2
Gene Diseases
The DLK1 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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