DLK1-CCT5 Fusion FISH Probe
The DLK1-CCT5 Fusion FISH Probe is used to confirm a fusion of the DLK1 and CCT5 genes. The fusion of the DLK1 and CCT5 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DLK1-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| DLK1-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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DLK1 Gene Summary
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]
Gene Name: Delta Like Non-canonical Notch Ligand 1
Chromosome: CHR14: 101193201 -101201467
Locus: 14q32.2
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The DLK1 CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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