DLG5-POLR3A Fusion FISH Probe
The DLG5-POLR3A Fusion FISH Probe is used to confirm a fusion of the DLG5 and POLR3A genes. The fusion of the DLG5 and POLR3A genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DLG5-POLR3A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-RERE | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-REOR | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-REGO | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-REGR | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-REAQ | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-ORRE | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-OROR | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-ORGO | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-ORAQ | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-GORE | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-GOOR | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-GOGO | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-GOGR | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-GOAQ | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-GRRE | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-GROR | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-GRGO | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-GRGR | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-GRAQ | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-AQRE | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-AQOR | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-AQGO | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-AQGR | 20 (40 μL) | 200 μL |
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| DLG5-POLR3A-20-AQAQ | 20 (40 μL) | 200 μL |
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DLG5 Gene Summary
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Discs Large MAGUK Scaffold Protein 5
Chromosome: CHR10: 79550548 -79686348
Locus: 10q22.3
POLR3A Gene Summary
The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011]
Gene Name: RNA Polymerase III Subunit A
Chromosome: CHR10: 79734906 -79789298
Locus: 10q22.3
Gene Diseases
The DLG5 POLR3A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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