DLG4-BBS2 Fusion FISH Probe
The DLG4-BBS2 Fusion FISH Probe is used to confirm a fusion of the DLG4 and BBS2 genes. The fusion of the DLG4 and BBS2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DLG4-BBS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-RERE | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-REOR | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-REGO | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-REGR | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-REAQ | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-ORRE | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-OROR | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-ORGO | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-GORE | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-GOOR | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-GOGO | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-GOGR | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-GRRE | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-GROR | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-GRGO | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-GRGR | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-AQRE | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-AQOR | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-AQGO | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-AQGR | 20 (40 μL) | 200 μL |
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| DLG4-BBS2-20-AQAQ | 20 (40 μL) | 200 μL |
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BBS2 Gene Summary
This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with seven other BBS proteins.[provided by RefSeq, Oct 2014]
Gene Name: Bardet-Biedl Syndrome 2
Chromosome: CHR16: 56518258 -56554008
Locus: 16q13
DLG4 Gene Summary
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Discs Large MAGUK Scaffold Protein 4
Chromosome: CHR17: 7093209 -7123369
Locus: 17p13.1
Gene Diseases
The DLG4 BBS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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