DLG1-CBFA2T2 Fusion FISH Probe
The DLG1-CBFA2T2 Fusion FISH Probe is used to confirm a fusion of the DLG1 and CBFA2T2 genes. The fusion of the DLG1 and CBFA2T2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DLG1-CBFA2T2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-RERE | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-REOR | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-REGO | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-REGR | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-REAQ | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-ORRE | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-OROR | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-ORGO | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-GORE | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-GOOR | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-GOGO | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-GOGR | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-GRRE | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-GROR | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-GRGO | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-GRGR | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-AQRE | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-AQOR | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-AQGO | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-AQGR | 20 (40 μL) | 200 μL |
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| DLG1-CBFA2T2-20-AQAQ | 20 (40 μL) | 200 μL |
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DLG1 Gene Summary
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011]
Gene Name: Discs Large MAGUK Scaffold Protein 1
Chromosome: CHR3: 196769430 -197025447
Locus: 3q29
CBFA2T2 Gene Summary
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Gene Name: CBFA2/RUNX1 Translocation Partner 2
Chromosome: CHR20: 32077927 -32237837
Locus: 20q11.21-q11.22
Gene Diseases
The DLG1 CBFA2T2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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